Dorothy Never - fat - lives alone in New York, spending her days alone ever since the downfall of her guru, the Ayn Rand-like Anna Granite. Justine Shade - thin - finds herself only able to connect with people who will hurt her, and is writing an article about Anna Granite, her philosophy of Definitism, and her loyal followers.

They are drawn together with an intense magnetism. As we learn the stories of their lives, we understand the extent to which each girl is shaped by the dark trauma of their childhoods. In a magnificently incisive psychological portrait, Mary Gaitskill forensically draws threads that show how these characters search for connection in a world that has damaged them so.